Chrysaora hysoscella function as a male upon maturity and then develop female gametes, meaning this organism is protandrously hermaphroditic.

Chrysaora hysoscella utilize both sexual and asexual reproduction throughout development. Mature individuals reproduce sexually by broadcast spawning. Males release sperm from their mouths into the water column. Females fertilize the sperm internally and can fertilize sperm from multiple male partners. The larvae released from the female settle as benthic polyps that reproduce asexually. The polyps release multiple ephyrae through strobilation.